"Gut microbiota manipulation through probiotics oral administration restores glucose homeostasis in a mouse model of Alzheimer's disease"
1) We demonstrate that probiotics oral administration improves glucose uptake in 3xTg-AD mice by restoring the brain expression levels of key glucose transporters (GLUT3, GLUT1) and insulin-like growth factor receptor β.
2) In parallel, phosphorylated tau aggregates decrease in treated mice.
3) Probiotics counteract the time-dependent increase of glycated hemoglobin and the accumulation of advanced glycation end products in AD mice, consistently with memory improvement".
https://www.sciencedirect.com/science/article/pii/S0197458019303938?via%3Dihub
Neurobiol Aging. 2020 Mar;87:35-43.
我們證明，口服益生菌可通過恢復關鍵葡萄糖轉運蛋白（GLUT3、GLUT1）和胰島素樣生長因子受體 β 的腦表達水平來改善 3xTg-AD 小鼠的葡萄糖攝取。 同時，在益生菌處理的小鼠中，磷酸化的 tau 聚集體減少。 益生菌抵消了糖化血紅蛋白的時間依賴性增加和 AD 小鼠糖化終產物的積累，與記憶力改善一致。
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